Resveratrol

Resveratrol is an antioxidant found in grapes and other plants that’s been studied for its antioxidant, anti-inflammatory, and anti carcinogenic effects when ingested and also when applied topically.

Studies show that it can improve skin elasticity, firmness, and reduce the appearance of fine lines and wrinkles. It also exhibits antioxidant and anti-inflammatory effects, potentially protecting against sun damage and other environmental stressors. 

Resveratrol can help soothe irritated skin and potentially aid in conditions like eczema and psoriasis. 

One study found that a nighttime topical antioxidant containing 1% resveratrol, baicalin, and vitamin E significantly improved fine lines, wrinkles, firmness, and elasticity in 12 weeks. Ultrasound showed increased skin density and biomarkers revealed an increase in collagen III and hemoxygensase 1 production.

Another study showed that resveratrol can reduce redness and improve skin quality, especially in those with sun-damaged skin. 

In a comparative study, a 1% resveratrol cream was compared to 1% idebenone cream using the standard ORAC test for antioxidant activity. The resveratrol cream was found to have a 17-times-greater antioxidant capacity than the idebenone product.  

Sources:

Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin. J Drugs Dermatol 2014

Skin Anti-Aging Benefits of a 2% Resveratrol Emulsion. Journal of Cosmetics, Dermatological Sciences and Applications 2021

The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges. Arch Biochem Biophys 2011

Resveratrol as a factor preventing skin aging and affecting its regeneration. Postepy Dermatol Alergol. 2022