Matrixyl™ Synthe’6

Matrixyl™ Synthe'6 is the brand name of a wrinkle reducing “matrikine-mimetic” peptide (aka Palmitoyl Tripeptide-38) known for its ability to enhance skin elasticity and reduce the appearance of fine lines and wrinkles.

Matrixyl™ Synthe'6 works with the natural structure of the skin’s matrix to produce a visible smoothing and lifting effect. It’s been shown in studies to stimulate 6 major constituents of the skin’s extracellular matrix (ECM) and the dermal–epidermal junction (DEJ)  boosting production of collagen I, III, IV, fibronectin, hyaluronic acid and laminin 5 which provide it’s wrinkle reducing effects that are particularly effective on the forehead and crow’s feet.

Matrixyl™ Synthe’6 also helps to balance the activity of matrix metalloproteinases (MMPs), enzymes that can degrade collagen and contribute to skin aging. It’s also been shown to be hydrating by increasing hyaluronic acid production in the skin without being irritating.

In one study, daily application of a face serum containing palmitoyl tetrapeptide-38 for 30 days significantly increased skin hydration, with all 35 volunteers experiencing improvement. Substantial improvements in skin elasticity, roughness (fine lines and wrinkles), and brightness also occurred during the trial.

In another study, 35 female subjects with a mean age of 64 years used a serum containing vitamin C, Vitamin E and Matrixyl Synthe’6 for 56 days. Once-daily use of the serum containing both preventative antioxidants and a matrix-restoring peptide resulted in clinically visible and statistically significant improvements in the signs of aging with smoothing, skin-tone brightening, as well as anti-wrinkle and isotropy restructuring effects, as measured by objective instrumental protocols.

Clinical studies show that, after 2 months daily use using 2% of the active, forehead and crow’s feet wrinkles are visibly smoothed.

Sources:

A Face Serum Containing Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid, Bakuchiol and a Polyherbal and Vitamin Blend Improves Skin Quality Journal of Cosmetics Dermatological Sciences and Applications 2021

A serum containing vitamins C & E and a matrix‐repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto‐perception. Journal of Cosmetic Dermatology 2020

A comparative study on the anti-wrinkle benefits of an active complex (Palmitoyl Tripeptide-38, Silybum marianum fruit extract, Hyaluronic acid (HA), and Chenopodium quinoa seed extract) Aesthetic Medicine 2023