Matrixyl™ 3000
Matrixyl™ 3000 is the brand name of a wrinkle reducing peptide that combines 2 “messenger” or “signaling” peptides: Palmitoyl Tripeptide-1 (formerly known as palmitoyl oligopeptide or Pal-GHK) and Palmitoyl Tetrapeptide-7.
These peptides work by sending repair signals to the skin that result in increased collagen production, skin damage repair, and strengthening skin’s supportive elements. Studies have shown ongoing use can lead to a reduction in wrinkle depth. It’s been shown in studies to reverse the signs of aging and target sun damage.
Matrixyl™ 3000 stimulates collagen I, III and VI, fibronectin, elastin and glucosamnoglycans production.
Both peptides that make up Matixyl 3000 have been shown to stimulate collagen, fibronectin, and hyaluronic acid production on their own, but when combined the production stimulated was much greater than each acting alone.
In a study on 15 women, a cream containing palmitoyl tripeptide-1 was applied twice
daily for four weeks, leading to statistically significant reductions in wrinkle length, depth and skin roughness.
A blind, randomized clinical study with 28 volunteers twice daily applying cream including the active compound to half their face and one of their forearms and a placebo cream to the other half of the face and other forearm confirmed anti-wrinkle efficacy, reduction of wrinkle depth, volume and density, skin roughness and complexity, as well as a decrease of the area occupied by deep wrinkles, and an increase in skin tone
An in-vitro study showed that palmitoyl oligopeptide stimulates collagen production in a concentration-dependent manner, meaning that better results were achieved when more of the peptide was used.
Sources:
Biologically active peptides: From a laboratory bench curiosity to a functional skincare product. Int. J. Cosmet. Sci. 2000
Clinical evidence of the efficacy and safety of a new multi-peptide anti-aging topical eye serum. Journal of Cosmetic Dermatology 2023
Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Clin Cosmet Investig Dermatol. 2016
Safety Assessment of Palmitoyl Oligopeptides as Used in Cosmetics. 2012
New Cosmetic or Dermopharmaceutical Topical Use of a Mixture of a Ghk Tripeptide and Gqpr Tetrapeptide Sederma Patent 2012
Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Molecular Pharmacology 2013
Topical peptide treatments with effective anti-aging results. Cosmetics 2017
US patent 2004/0132667 A1